From the New Jersey Turnpike (I-95) and points west, there are three Hudson River crossings into the city's west side: the Holland Tunnel (lower Manhattan), the Lincoln Tunnel (Midtown), and the George Washington Bridge (upper Manhattan).

From upstate New York, take the New York State Thruway (I-87), which crosses the Hudson on the Tappan Zee Bridge and becomes the Major Deegan Expressway (I-87) through the Bronx. For the east side, continue to the Triborough Bridge and then down the FDR Drive. For the west side, take the Cross Bronx Expressway (I-95) to the Henry Hudson Parkway or the Taconic State Parkway to the Saw Mill River Parkway to the Henry Hudson Parkway south.

From New England, the New England Thruway (I-95) connects with the Bruckner Expressway (I-278), which leads to the Triborough Bridge and the FDR Drive on the east side. For the west side, take the Bruckner to the Cross Bronx Expressway (I-95) to the Henry Hudson Parkway south.

Note that you'll have to pay tolls along some of these roads and at most crossings.

Once you arrive in Manhattan, park your car in a garage (expect to pay $20-$45 per day) and leave it there. Don't use your car for traveling within the city. Public transportation, taxis, and walking will easily get you where you want to go without the headaches of parking, gridlock, and dodging crazy cabbies.